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Also known as 20-Hydroxyecdysone and 20E, Ecdysterone is a naturally occurring Ecdysterone 1 Canadian Academy of Sports Nutrition caasnhormone from the Ecdysteroids family. They are arthropod steroid hormones that are mainly responsible for the molting process known as "ecdysis" in arthropods. It is famous among athletes as "insect hormone". 

Phytoecdysteroids are ecdysteroids extracted from the plants. The plants produce these chemicals as a defense mechanism to protect themselves from being eaten by insects. Spinach and asparagus are among those plants that synthesize these hormones. Other plants that produce phytoecdysteroids are Maral Root, Cordyceps Sinensis, Ox knee (Achyranthes bidentata), Heart-Leaved Moonseed (Tinospora cordifolia), Brazilian Ginseng (Pfaffia paniculata; Suma), and Plumeless Saw-Wort (Serratula).

Other names for Ecdysterone are Beta-ecdysone, Beta Ecdysterone, Ecdisten, Ecdysone, Ecdystérone, Ecdysterona, Hydroxyecdysterone, Isoinokosterone, Leuzea Extract, and Viticosterone.

Ecdysterone in Sports:

 As a natural anabolic agent, Ecdysterone is claimed to enhance athletic performance. This was why the WADA (World Anti-Doping Agency) has included it in the Monitoring Program to assess the patterns and prevalence of misuse among athletes since January 01, 2020.

Ecdysteroids (insect and plant-based) have been extensively touted to increase muscle growth, delay fatigue, and accelerate recovery. From extensive research in animals and humans, it appears that they can increase protein synthesis. It is believed that Russian Olympic athletes have used Ecdysterone in the 1980s. According to a study in Russia in 1976, Ecdysterone extracted from the plant Maral Root (also known as Rhaponticum carthamoides) increased protein synthesis and body weight.

How Ecdysterone Works:

Some studies claim that the anabolic activity of Ecdysterone is comparable to SARMs (selective androgen receptor modulators) and IGF-I. Contrary to conventional anabolic agents, Ecdysterone appears to show its anabolic effects by binding to estrogen receptor beta (ERβ), acting like the SERMs (selective estrogen receptor modulators). ERβ is also a potent anti-tumor and demonstrates a vital activity against prostate cancer.

Ecdysterone doesn't increase testosterone levels. Some claim that Ecdysterone can also increase the production of erythropoietin (EPO) hormone from the kidneys and liver, improving oxygenation and ultimately endurance in athletes.

Athletic Benefits of Ecdysterone: Ecdysterone 2 Canadian Academy of Sports Nutrition caasn

1) Increases protein synthesis and promotes muscle growth.

2) Delays fatigue and exhaustion.

3) Accelerates exercise recovery.

4) May protect against overtraining syndrome (OTS).

5) May improve quality of sleep.

Non-Athletic Benefits of Ecdysterone:

The following conditions may benefit from Ecdysterone:

1) Weak immune system.

2) Cancers.

3) Sexual dysfunction.

4) Wound healing.

5) Alzheimer's disease.

6) Depression.

7) Infertility in men.

8) Parasite infestation.

Dose and Side Effects:

The Ecdysterone supplements in the market are mainly plant-based with Maral Root (Rhaponticum carthamoides) and Cyanotis Vaga being the common sources. They usually come in pure forms or combined with other ingredients. The fact that Ecdysterone does not convert into estrogen has made it popular among athletes.

The usual dose among athletes is 500-2000 mg daily. It can be taken in divided doses, or the whole dose immediately after a training session with protein. For better results, athletes combine it with a testosterone booster such as Tribulus Terrestris or Maca root, HMB, Colostrum, and L-Leucine.

No side effects have been reported.